Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions.
Vinay Swaminathan, Joseph Mathew Kalappurakkal, Shalin B. Mehta, Pontus Nordenfelt, Travis I Moore, Koga Nobuyasu, David A. Baker, Rudolf Oldenbourg, Tomomi Tani, Satyajit Mayor, Timothy A Springer, Clare M Waterman
The paper shows that actin retrograde flow aligns and orients ligand-bound integrins in focal adhesions through force-induced structural changes.
bioRxiv · Aug 27, 2016Cell Biology