Pontus Nordenfelt

Mechanical memory of confinement pressure governs expansion size in epithelial monolayers

The paper shows epithelial monolayers converge to the same final size and density after release from confinement, regardless of initial conditions, through mechanical pressure signaling.

NucleiSky enables cross-scale multimodal registration of microscopy data using nuclei constellations

NucleiSky registers microscopy images across scales and modalities by aligning nuclei constellations, achieving accurate localization with minimal landmarks.

ECM-stiffness mediated persistent fibroblast activation requires integrin and formin dependent chromatin remodeling

This study shows that prolonged exposure to stiff ECM activates fibroblasts through integrin and formin pathways, leading to persistent activation and fibrosis, with chromatin remodeling playing a key role.

Smart Microscopy: Current Implementations and a Roadmap for Interoperability

This paper reviews current smart microscopy implementations and proposes a framework for interoperability to improve collaboration and standardization in the field.

Cellular and biophysical barriers to lipid nanoparticle mediated delivery of RNA to the cytosol

This study identifies multiple barriers to efficient cytosolic delivery of RNA by lipid nanoparticles, including endosomal sorting and membrane damage mechanisms.

β1 Integrin-FAK-Piezo1 signalling axis drives in-situ stiffening mediated ECM remodelling and invasion of 3D breast epithelium

Cardiomyocyte antisense transcription regulates exon usage in the elastic spring region of Titin to modulate sarcomere function

This study shows that TTN-AS1-276 antisense transcript regulates TTN alternative splicing and sarcomere function in cardiomyocytes.

Data-driven microscopy allows for automated targeted acquisition of relevant data withhigher fidelity

This paper introduces data-driven microscopy (DDM), a framework that enhances imaging fidelity by combining population-wide characterization with adaptive imaging techniques.

Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions.

The paper shows that actin retrograde flow aligns and orients ligand-bound integrins in focal adhesions through force-induced structural changes.