Shalin B. Mehta

The paper presents a multimodal perturbation atlas using CRISPR knockouts in A549 cells, combining microscopy, phase imaging, and scRNA-seq to assess phenotypic resolution.

V-SWITCH is a fluorescent reporter that detects viral infections by switching from OFF to ON fluorescence, enabling live-cell tracking and screening for antiviral strategies.

This paper introduces an algorithm to reconstruct 3D molecular orientation and density from polarized fluorescence microscopy data, demonstrating its application on biological structures and dynamics.

Ultrack improves cell tracking across 2D, 3D, and multi-channel time-lapse recordings by integrating multiple segmentations and temporal consistency, achieving state-of-the-art performance on benchmark datasets.

The paper introduces a polarized dual-view light-sheet microscope to recover 3D orientations and positions of fluorescent dipoles, validated with experiments on biological samples.

The paper develops robust virtual staining methods for cellular landmarks using deep learning, showing improved performance across cell types and imaging conditions.

DynaMorph uses self-supervised learning to analyze morphodynamic states of live human microglia, identifying distinct states and transitions in response to disease-relevant stimuli.

This study maps human microglia development and identifies cytokine-associated subtypes and functional roles in neural network maturation.

This paper introduces a fluorescence polarization microscope to track molecular orientation and position in live cells, revealing dynamic structural properties of actin and septin assemblies.

The paper shows that actin retrograde flow aligns and orients ligand-bound integrins in focal adhesions through force-induced structural changes.