Vinay Swaminathan

Mechanical memory of confinement pressure governs expansion size in epithelial monolayers

The paper shows epithelial monolayers converge to the same final size and density after release from confinement, regardless of initial conditions, through mechanical pressure signaling.

ECM-stiffness mediated persistent fibroblast activation requires integrin and formin dependent chromatin remodeling

This study shows that prolonged exposure to stiff ECM activates fibroblasts through integrin and formin pathways, leading to persistent activation and fibrosis, with chromatin remodeling playing a key role.

METTL3 regulates exocytosis independently of m6A

This study identifies a non-catalytic role of METTL3 in regulating exocytosis and the cancer secretome through stabilization of EXOC7.

Packing-Driven Mechanotransduction: local crowding overrides adhesion and stiffness cues for YAP Activation in Cellular Collectives

This study shows that local cell packing fraction, not adhesion or stiffness, drives YAP activation in multicellular collectives, independent of single-cell mechanisms.

Observing biological spatio-angular structures and dynamics with statistical image reconstruction and polarized fluorescence microscopy

This paper introduces an algorithm to reconstruct 3D molecular orientation and density from polarized fluorescence microscopy data, demonstrating its application on biological structures and dynamics.

β1 Integrin-FAK-Piezo1 signalling axis drives in-situ stiffening mediated ECM remodelling and invasion of 3D breast epithelium

Human mitochondrial transfer modeling reveals biased delivery from mesenchymal-to-hematopoietic stem cells

The paper develops iMSOD-mito, a tool to model human mesenchymal-to-hematopoietic mitochondrial transfer, showing preferential transfer to hematopoietic stem cells and functional impacts.

Data-driven microscopy allows for automated targeted acquisition of relevant data withhigher fidelity

This paper introduces data-driven microscopy (DDM), a framework that enhances imaging fidelity by combining population-wide characterization with adaptive imaging techniques.

Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions.

The paper shows that actin retrograde flow aligns and orients ligand-bound integrins in focal adhesions through force-induced structural changes.