AAV-Delivered Anti-PC-OxPL Antibody Fragments: A NovelTherapeutic Approach to Target ALS
Andreia Gomes‐Duarte, Jamie K. Wong, Alessandro Moro, Svetlana Pasteuning-Vuhman, Wouter Pos, Rob Haselberg, Marina Sogorb-González, Sofia Pascoal, Linda Borst, Madhurima Chatterjee, Martin A. Giera, Sotirios Tsimikas, Saud A. Sadiq, Sander J. H. van Deventer
This paper develops an AAV-delivered scFv antibody targeting PC-OxPL to reduce neurotoxicity and motor neuron death in ALS models.
Molecular Therapy Advances · Jul 29, 2026Peer-reviewedNeuroscience