Martin A. Giera

CPMsi is a computational pipeline that efficiently processes and integrates large-scale MSI data, enabling faster analysis and discovery of molecular patterns across tissue sections.

This study shows ABCA7 deficiency in microglia disrupts lysosomal and lipid homeostasis, impairs phagocytosis, and negatively affects neuronal health in Alzheimer's disease.

This study shows APOE genotypes alter astrocytic lipid droplet proteomes and dynamics, with APOE4 showing resistance to lipophagy, suggesting impaired clearance as a mechanism for AD risk.

The paper uses spatial metabolomics and transcriptomics to identify persistent metabolic failure in kidney niches after ischemia-reperfusion injury, highlighting mitochondrial dysfunction in otherwise healthy areas.

This paper develops an AAV-delivered scFv antibody targeting PC-OxPL to reduce neurotoxicity and motor neuron death in ALS models.

This study identifies two novel biosynthetic intermediates and characterizes their enzymes in the unique glycan modification pathway of C. difficile flagellin.

This study introduces Stereo-meta-seq to integrate spatial metabolomics and transcriptomics in human kidney development, revealing DHA's role in proximal tubule maturation.

This study identifies VAPB and AKAP11 as regulators of lipid droplet homeostasis by mediating neutral lipid degradation through membrane contact sites and PKA activity.

The paper introduces the Neurolipid Atlas, a lipidomics resource for neurodegenerative diseases, revealing that ApoE4 impairs astrocyte reactivity by promoting cholesterol ester accumulation.

Totum-448 reduces hepatic steatosis and inflammation in diet-induced MASLD mice without affecting body weight or microbiota.

This paper introduces a quantitative MSI workflow using 13C-labeled yeast extract to enable reliable spatial metabolomics, revealing metabolic changes in the ipsilateral cortex after stroke.

This study shows that normothermic kidney preservation with red blood cells causes iron accumulation and ferroptosis, leading to kidney injury, and suggests alternatives to mitigate these effects.

This study identifies IL-6's role in elevating thrombosis in RA via platelet 12-lipoxygenase-generated pro-coagulant phospholipids.

The paper identifies reduced PUFA levels in FTD/ALS models and shows neuronal PUFA supplementation improves survival and reduces neuronal death.

This study shows that inhibiting ACC disrupts MERS-CoV particle release but not replication organelle formation, highlighting ACC as a potential antiviral target.

iSODA is a web-based tool for analyzing single- and multi-omics data, offering visualization, normalization, and integration methods like MOFA and SNF.

This study compares the effects of moderate and vigorous exercise on intestinal damage, stress response, inflammation, and gut microbiota in mice, finding that daily moderate exercise causes more severe injury than vigorous training with rest days.

This study shows that microbiota-derived short chain fatty acids (SCFA) increase Aβ plaque deposition in Alzheimer's disease by promoting microglial activation and ApoE upregulation.