Spinal Noradrenergic Overdrive Promotes Reversible Motor Unit Aging and Sarcopenia
Zhongmin Wang, Valentina Grinevich, Maria Laura Messi, Savannah Longo, Ragunath Muthu, William Meeker, Evgeny Budygin, Osvaldo Delbono
This study shows that aging increases spinal noradrenergic activity, leading to motor neuron hyperexcitability and sarcopenia, which can be reversed by suppressing noradrenergic signaling.
bioRxiv · Nov 3, 2026 · PreprintNeuroscience