Osvaldo Delbono

This study shows that aging increases spinal noradrenergic activity, leading to motor neuron hyperexcitability and sarcopenia, which can be reversed by suppressing noradrenergic signaling.

This study shows that mitochondria-containing large extracellular vesicles (lEVs) improve mitochondrial function in heat-stressed neurons and deliver mitochondria to motor neurons in vivo.