Structural and functional clues challenge the hypothesis that the yjdF riboswitch is natively regulated through broad recognition of azaaromatic compounds
Savannah Spradlin, Kyle A Dickerson, Robert Batey
The paper challenges the hypothesis that the yjdF riboswitch is regulated by azaaromatic compounds by showing it binds multiple ligands similarly but requires conserved nucleotides for activation.
Nucleic Acids Research · Nov 13, 2025Peer-reviewedBiochemistry