Cancer BiologybioRxivPreprint
Loss of UBP1 drives oxaliplatin resistance through a targetable dependency on translation initiation
Moustafa Abohawya, Tim Schmäche, Julia Dietzel…·Jovan Mirectic
The paper identifies UBP1 loss as a driver of oxaliplatin resistance in gastric cancer by revealing a compensatory reliance on translation initiation, which can be targeted with 4EGI.
DOI 10.64898/2026.05.18.725866