Maciej Paszkowski‐Rogacz

Loss of UBP1 drives oxaliplatin resistance through a targetable dependency on translation initiation

The paper identifies UBP1 loss as a driver of oxaliplatin resistance in gastric cancer by revealing a compensatory reliance on translation initiation, which can be targeted with 4EGI.

Prediction of designer-recombinases for DNA editing with generative deep learning

The paper introduces RecGen, a deep learning model that generates designer-recombinases for novel DNA target sites, outperforming traditional directed evolution methods.

Correction of a Factor VIII genomic inversion with designer-recombinases

This study corrects a 140 kb genomic inversion in the F8 gene using a designer recombinase system, restoring Factor VIII mRNA expression in patient-derived cells.

Comparative RNAi Screens in Isogenic Human Stem Cells Reveal SMARCA4 as a Differential Regulator

The paper uses RNAi screens in isogenic human stem cells to identify SMARCA4 as a differential regulator of stemness and differentiation in hematopoietic and neural stem cells.