Frank Buchholz

Loss of UBP1 drives oxaliplatin resistance through a targetable dependency on translation initiation

The paper identifies UBP1 loss as a driver of oxaliplatin resistance in gastric cancer by revealing a compensatory reliance on translation initiation, which can be targeted with 4EGI.

NCBP2-AS2 is a mitochondrial microprotein, regulates energy metabolism and neurogenesis, and is downregulated in Alzheimer's disease

TOBF1 modulates mouse embryonic stem cell fate through co-transcriptional regulation of alternative splicing

This study identifies TOBF1 as a regulator of alternative splicing in mouse embryonic stem cells, showing its role in maintaining stem cell identity through co-transcriptional mechanisms.

Prediction of designer-recombinases for DNA editing with generative deep learning

The paper introduces RecGen, a deep learning model that generates designer-recombinases for novel DNA target sites, outperforming traditional directed evolution methods.

Correction of a Factor VIII genomic inversion with designer-recombinases

This study corrects a 140 kb genomic inversion in the F8 gene using a designer recombinase system, restoring Factor VIII mRNA expression in patient-derived cells.

Large-scale dissection suggests that ultraconserved elements are dispensable for mouse embryonic stem cell survival and fitness

The paper withdraws its findings on ultraconserved elements in mouse embryonic stem cells due to inconsistencies in knockout results.

Comparative RNAi Screens in Isogenic Human Stem Cells Reveal SMARCA4 as a Differential Regulator

The paper uses RNAi screens in isogenic human stem cells to identify SMARCA4 as a differential regulator of stemness and differentiation in hematopoietic and neural stem cells.