Neural CXCR4 contributes to neuroimmune modulation of atherosclerosis in a cardio-metabolic Ldlr-/- mouse model
Yaqi Sun, Robby Zachariah Tom, Anna Goetz, Sebastian Cucuruz, Annette Feuchtinger, Dominik Lutter, Yvonne J. F. M. Jansen, Christian Weber, Yvonne Döring, Cristina García‐Cáceres, Aphrodite Kapurniotu, Jürgen Bernhagen, Timo D. Mueller, Susanna M. Hofmann
This study shows that neural CXCR4 reduces atherosclerotic plaque formation in mice without affecting metabolism or immune cells, and identifies MIF-CXCR4 signaling in the PVN as a potential neuroimmune pathway in atherosclerosis.
bioRxiv · Dec 18, 2025 · PreprintImmunology