Jürgen Bernhagen

The paper identifies MIF-2-CCL20 complex formation in liver fibrosis through biochemical and computational methods, showing its role in modulating immune and stromal responses.

This study shows that neural CXCR4 reduces atherosclerotic plaque formation in mice without affecting metabolism or immune cells, and identifies MIF-CXCR4 signaling in the PVN as a potential neuroimmune pathway in atherosclerosis.

This study shows that Galectin-1 reduces atherosclerotic plaque formation by reprogramming macrophages and modulating T cell immunity through both glycan-dependent and -independent mechanisms.

The paper identifies CD74+ microglia/macrophages driven by MIF as clinically relevant subpopulations in brain metastasis and other CNS disorders, showing their role in disease progression and therapeutic targeting potential.

This study identifies genetic variants associated with circulating cytokine levels and suggests potential drug targets for immune-related diseases.

The paper uses proteogenomic integration to identify CXCL10 as a mediator of IL-6 signaling effects on atherosclerosis, showing its association with cardiovascular disease risk and lesion characteristics.

This study identifies ADAMTS-7 as a risk factor for atherosclerosis by degrading TIMP-1, reducing its inhibition of MMP-9 and promoting collagen degradation.

The paper shows that HMGA2 induces DNA nicks required for nucleosome incorporation containing H2A.X, which is necessary for DNA demethylation and transcription initiation.