Molecular Basis for Asynchronous Chain Elongation During Rifamycin Antibiotic Biosynthesis
Chengli Liu, Ryan C. West, Muyuan Chen, Whitaker Cohn, George Wang, Selena Kim, Aryan M. Mandot, Kym Francis Faull, Dillon P. Cogan
This paper investigates the biosynthetic mechanism of the rifamycin synthetase (RIFS) using crosslinking, kinetic, and structural analyses, revealing how C-terminal dimeric interfaces influence chain elongation asymmetry.
Journal of Biological Chemistry · May 6, 2026Peer-reviewedBiochemistry