BiochemistryJournal of Biological ChemistryPeer-reviewed
Molecular Basis for Asynchronous Chain Elongation During Rifamycin Antibiotic Biosynthesis
Chengli Liu, Ryan C. West, Muyuan Chen…·Dillon P. Cogan
This paper investigates the biosynthetic mechanism of the rifamycin synthetase (RIFS) using crosslinking, kinetic, and structural analyses, revealing how C-terminal dimeric interfaces influence chain elongation asymmetry.
DOI 10.1016/j.jbc.2026.113119