Muyuan Chen

This study determines the structural changes in a Type II ABC importer's substrate-binding protein in different nucleotide states, revealing how ATP binding and hydrolysis regulate its conformation and interaction with the transporter.

The paper determines the in vivo structures of P22 infection intermediates and explains how gp10 templates the sequential assembly of three proteins into a trans-envelope channel for genome translocation.

The paper investigates how BIM1 selectively inhibits CLC-Ka over CLC-Kb by analyzing cryo-EM structures and showing that interactions with a conserved lysine and dynamic gating-loop behavior underlie this selectivity.

This paper investigates the biosynthetic mechanism of the rifamycin synthetase (RIFS) using crosslinking, kinetic, and structural analyses, revealing how C-terminal dimeric interfaces influence chain elongation asymmetry.

This study uses cryo-ET to visualize NLRP3 inflammasome condensates at the MTOC during activation, revealing structural changes and pyroptosis in macrophages.

This study improves CryoET tomogram contrast and protein structure resolution by refining tilt-series alignment using gradient descent.

The paper uses cryo-ET to show IFT trains dock at specific MTD positions in trypanosome flagella, revealing spatial regulation independent of IFT-B structure.

The paper determines RubisCO structures in Chlamydomonas reinhardtii using CryoET, revealing their arrangement and interactions within the pyrenoid.

The paper uses cryo-ET to study mitochondrial ATP synthase dynamics in Chlamydomonas reinhardtii, revealing conformational states and movement patterns of its components.

The paper uses cryogenic electron tomography to redefine herpesvirus capsid assembly intermediates inside the cell nucleus by deriving atomic models and revealing structural heterogeneity in capsid components.

This paper introduces a method to generate molecular model series from CryoEM datasets, capturing conformational dynamics with high geometric accuracy.

The paper investigates intermodular communication in polyketide biosynthesis using cryo-EM and crosslinking, revealing structural insights for designing hybrid synthases.

This study uses cryoET to observe the 3D organization of dsDNA in viral particles, revealing a conserved 'rod-and-coil' structure and proposing a packaging mechanism.

The paper demonstrates rendering protein structures at the atomic level inside cells using a video game engine and provides tools for interactive visualization.

This study uses cryo-electron tomography to reveal the molecular structures of two tubulin-based cytoskeleton structures in Toxoplasma gondii, showing their architecture and role in invasion.