Whitaker Cohn

This study shows ApoE isoforms influence antioxidant pathways differently across aging, with ApoE4 showing stronger transcriptional responses but less effective protein production, linking to neurodegenerative risk.

This study shows that mtDNA mutations arising early in life drive age-related pathologies and that mitochondrial fusion modulates their selection, suggesting interventions targeting fusion could slow aging.

This paper develops a small molecule that disaggregates tau fibrils and oligomers, reduces pathology, and preserves function in a tauopathy mouse model.

This paper investigates the biosynthetic mechanism of the rifamycin synthetase (RIFS) using crosslinking, kinetic, and structural analyses, revealing how C-terminal dimeric interfaces influence chain elongation asymmetry.

This study maps age- and sex-related lipid changes across 10 mouse organs, revealing organ-specific and sex-dependent patterns in the lipidome during aging.

This study maps metabolic changes in 12 organs of male and female mice across 5 ages, identifying sex-specific patterns and a metabolic aging clock.

This study identifies Aster-A as a cholesterol transporter in T cells that regulates immune signaling and metabolic responses by controlling membrane cholesterol levels.

This paper identifies an APP-selective BACE1 inhibitor, FAH65, which shows substrate and enzyme selectivity, reduces Aβ levels, and improves cognitive performance in an AD mouse model.

The paper identifies LPCAT3 as a cold-regulated enzyme that generates AA-PE in BAT mitochondria, enhancing ETC efficiency and thermogenesis.

This study identifies ZPR9 as a DUSP12 interactor and shows DUSP12 promotes cell cycle progression and protects cells from stress-induced apoptosis by de-phosphorylating ZPR9.

The paper identifies a small molecule that enhances gamma-oscillations and improves cognition in Alzheimer's disease model mice by modulating GABAARs.