Bifunctional Architecture Enables Substrate Catalysis and Channeling in Paracoccus TMAO Demethylase
Trung Thanh Thach, KanagaVijayan Dhanabalan, Shiwangi Maurya, Yu Han-Hallett, Senwei Quan, Jane R. Allison, Gurunath Ramanathan, Subramanian Ramaswamy
This study reveals a bifunctional mechanism in TMAO demethylase where HCHO is channeled from a catalytic core to a THF-binding site, linking TMAO demethylation with one-carbon transfer.
eLife · Sep 28, 2026Peer-reviewedBiophysics