Macrophages induce stromal differentiation and endothelialization in iPSC-derived kidney organoids.
Ekaterina Pecksen, Marc Vives Enrich, Mi-Sun Jang, Sergey Tkachuk, Tamar G. Kapanadze, Cory P. Johnson, Florian P. Limbourg, Nico Lachmann, Kai Martin Schmidt-Ott, Hermann G. Haller, Yulia Kiyan
This study shows that macrophages induce endothelial and stromal differentiation in kidney organoids, enhancing vascularization and maturation.
bioRxiv · Nov 13, 2025 · PreprintCell Biology