Jan Hegermann

This paper presents the first single-nucleus RNA sequencing atlas of pleuroparenchymal fibroelastosis, identifying novel cell states and their spatial organization in lung fibrosis.

This study shows that modGLA mRNA therapy reverses Fabry disease phenotypes in human iPSC-derived cardiomyocytes by restoring enzyme activity and normalizing molecular alterations.

The paper develops a method to detect polymicrobial amoxicillin resistance in oral biofilms and identifies beta-lactamase-producing species that confer cross-protection to other microbes.

This study identifies Gadlor1 and Gadlor2 as endothelial cell-derived lncRNAs that worsen cardiac remodeling through EV-mediated crosstalk with cardiomyocytes.

This study shows that Hpa2 regulates endothelial permeability and prevents proteinuria by modulating VEGFA and FGF signaling through HS shedding.

This study identifies NTE/SWS's role in maintaining BBB integrity and links its dysfunction to lysosomal storage diseases, inflammation, and fatty acid metabolism abnormalities.

The paper shows that cytosolic sodium accumulation triggers NLRP3 inflammasome activation in response to various danger signals in human macrophages.

This study shows that synaptopodin and the spine apparatus organelle are essential for lesion-induced synaptic plasticity at hippocampal mossy fiber synapses in mice.

The paper investigates myelin structural changes during development in mice and zebrafish, finding that myelin degeneration is resolved by microglia, while sheath retractions occur independently.