Author

Nico Lachmann

Medizinische Hochschule HannoverORCID 0000-0002-4245-1497Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Organism:mouse· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Alexandra HaaseiD· 1 shared André ZeugiD· 1 shared Andreas KirschningiD· 1 shared Andreas Martens· 1 shared Benjamin VoisiniD· 1 shared Christelle Le FolliD· 1 shared Clarissa-Laura Döring· 1 shared Conceição Elidianne Aníbal SilvaiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperMolecular Biology

Alexandra HaaseORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Macrophages induce stromal differentiation and endothelialization in iPSC-derived kidney organoids.

Ekaterina Pecksen, Marc Vives Enrich, Mi-Sun Jang, Sergey Tkachuk, Tamar G. Kapanadze, Cory P. Johnson, Florian P. Limbourg, Nico Lachmann, Kai Martin Schmidt-Ott, Hermann G. Haller, Yulia Kiyan

This study shows that macrophages induce endothelial and stromal differentiation in kidney organoids, enhancing vascularization and maturation.

bioRxiv · Nov 13, 2025 · PreprintCell Biology

Sensory neurons shape macrophage identity via TGF-β signalling

Julia Kolter, Clarissa-Laura Döring, Samah Sarout, Sebastian Baasch, Lloyd Steele, Reem Alsumati, Gabriel Victor Lucena da Silva, Conceição Elidianne Aníbal Silva, Isadora Marques Paiva, Zohreh Mansoori Moghadam, Vitka Gres, Florens Lohrmann, Philipp Aktories, Theresa Buchegger, Mitchell Bijnen, , Philipp Henneke

This study identifies TGF-β as a key mediator of macrophage specialization in the skin through interaction with sensory nerves.

Immunity · Sep 5, 2025Peer-reviewedImmunology

Targeted biallelic integration of an inducible Caspase 9 suicide gene for safer cellular therapies prevents development of drug-resistant escapees in human iPSCs

Stephanie Wunderlich, Alexandra Haase, Sylvia Merkert, Kirsten Jahn, Maximillian Deest, Silke Glage, Wilhelm Korte, Andreas Martens, Andreas Kirschning, André Zeug, Evgeni G. Ponimaskin, Gudrun Goehring, Mania Ackermann, Nico Lachmann, Thomas Moritz, , Ulrich Martin

This study introduces a biallelic inducible Caspase9 suicide gene system in hiPSCs to prevent drug-resistant escapees, showing no escapees in biallelic cells versus rare escapees in monoallelic cells.

bioRxiv · Sep 19, 2021 · PreprintMolecular Biology