Author
University of California, Los Angeles
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
3 papers
Recent·Most cited
Tammy Tan, Hariharan Jayashankar, Junming Guan…·Alexander I. Young
Family-based GWAS meta-analysis of 34 phenotypes shows standard GWAS effects carry sizeable confounding uncorrelated with direct genetic effects, while assortative mating likely inflates SNP heritability and genetic correlations.
Junming Guan, Seyed Moeen Nehzati, Daniel Jacob Benjamin, Alexander I. Young
The paper introduces novel estimators for family-based GWAS that increase power and robustness to population structure by improving imputation of missing parent genotypes and using a linear-mixed model.
Alexander I. Young, Seyed Moeen Nehzati, Stefania Benónísdóttir…·Augustine Kong
The paper develops a method to impute parental genotypes from sibling data to estimate direct and indirect genetic effects, finding that standard GWAS underestimates direct effects for several traits.