Augustine Kong

Family-based GWAS meta-analysis of 34 phenotypes shows standard GWAS effects carry sizeable confounding uncorrelated with direct genetic effects, while assortative mating likely inflates SNP heritability and genetic correlations.

The paper identifies genetic factors influencing participation in genetic studies by analyzing allele frequency differences in related individuals from the UK Biobank.

The paper develops a method to impute parental genotypes from sibling data to estimate direct and indirect genetic effects, finding that standard GWAS underestimates direct effects for several traits.

The paper introduces mendelian imputation to disentangle genotype-phenotype associations by leveraging family data, showing improved predictive power for educational attainment.

The paper identifies recurrent de novo mutations in sibling pairs and estimates their recurrence probabilities based on various factors.

This study introduces RDR, a method to estimate heritability while removing environmental bias, and applies it to 54,888 Icelanders to estimate heritability for 14 traits.

The paper shows that non-transmitted parental alleles affect a child's traits through their impact on parents and relatives, termed genetic nurture, with significant effects on educational attainment and other traits.