INTERFERON-REGULATORY FACTOR 7: A NEUROIMMUNE ROLE FOR VAPOR-INDUCED ESCALATIONS IN ETHANOL SELF-ADMINISTRATION
Dennis F. Lovelock, Joseph M Carew, Elizabeth M. McNair, Baylee R. Materia, Shadi Darawsheh, Anthony M Downs, Sarah E. Sizer, Samuel A McDonald, Zoé A. McElligott, Leon G. Coleman, Joyce Besheer
This study shows that chronic intermittent ethanol vapor exposure increases IRF7 levels in brain regions associated with alcohol self-administration and alters excitatory/inhibitory balance, contributing to escalated drinking.
bioRxiv · Apr 6, 2026 · PreprintNeuroscience