Joyce Besheer

The paper shows that pro-inflammatory microglia increase IRF7 levels and ethanol self-administration in rats during early abstinence, which is reduced by minocycline treatment.

A no-code clip-level active-learning platform combining pose, video and region-of-interest features trains rodent behavior classifiers (mean precision-recall AUC 0.90, 45 behaviors, eight assays) largely agreeing with expert human scoring.

This study links stress-coping behaviors during predator odor exposure to changes in decision-making in rats, showing correlations with impulsive choice and reward-related behaviors.

This study shows that chronic intermittent ethanol vapor exposure increases IRF7 levels in brain regions associated with alcohol self-administration and alters excitatory/inhibitory balance, contributing to escalated drinking.

This study shows that GLP-1 receptor agonists reduce alcohol's interoceptive effects in rats, supporting their potential as treatments for alcohol use disorder.

This study shows xylazine enhances fentanyl's interoceptive effects in rats, suggesting it may contribute to the risks of xylazine-adulterated fentanyl.

This study examines if alcohol vapor exposure affects individual differences in punished alcohol self-administration in rats, finding no significant effect.

This study evaluates the effects of SBI-553, a β-arrestin-biased allosteric modulator of NTSR1, on ethanol-related behaviors in rodents, finding reduced ethanol consumption and altered sensitivity to ethanol effects.

This study shows that predator odor stress increases male rats' sensitivity to alcohol via GABAA receptor changes in the prelimbic cortex, but not in females.

This study shows that predator odor exposure increases sensitivity to alcohol's interoceptive effects and boosts GABAergic gene expression in brain regions linked to stress and addiction.

This study shows that TLR3 agonism increases alcohol consumption in rats, with females being more sensitive to lower doses than males.

This study shows that TLR7 activation with imiquimod increases ethanol self-administration and induces TLR-related gene expression in rats, with sex-specific effects on drinking behavior and molecular responses.

This study investigates how mGlu2 and mGlu3 NAMs affect alcohol's interoceptive effects in rats, finding they reduce these effects in both sexes with potential sex differences in response.

This study investigates how mGlu3 NAM pretreatment affects behavioral and molecular changes in the insular cortex and BNST after predator odor exposure in rats.

The paper tests a CB1 receptor NAM, RTICBM-74, showing it reduces alcohol intake in rats without affecting locomotion or sucrose self-administration.

This study investigates the role of the nucleus reuniens in modulating context reactivity to predator odor stressor TMT in rats, showing context-dependent effects of RE inactivation on behavioral responses.

This study shows that central amygdala mineralocorticoid receptors influence alcohol self-administration in rats, with MR antagonists reducing alcohol consumption.

This study shows that repeated exposure to the predator odor TMT increases alcohol self-administration and alters amygdala response to alcohol in rats, suggesting a link between PTSD-like stress and AUD.

This study examines gene expression changes in male rats after TMT exposure, showing early and late molecular adaptations related to stress and excitatory synaptic function.

The paper examines how repeated stress affects norepinephrine release in the BNST of mice, finding increased release and reduced autoreceptor sensitivity.