Dennis F. Lovelock

Pro-inflammatory microglia drive escalated alcohol consumption during early abstinence

The paper shows that pro-inflammatory microglia increase IRF7 levels and ethanol self-administration in rats during early abstinence, which is reduced by minocycline treatment.

INTERFERON-REGULATORY FACTOR 7: A NEUROIMMUNE ROLE FOR VAPOR-INDUCED ESCALATIONS IN ETHANOL SELF-ADMINISTRATION

This study shows that chronic intermittent ethanol vapor exposure increases IRF7 levels in brain regions associated with alcohol self-administration and alters excitatory/inhibitory balance, contributing to escalated drinking.

Semaglutide, Tirzepatide, and Retatrutide Attenuate the Interoceptive Effects of Alcohol in Male and Female Rats

This study shows that GLP-1 receptor agonists reduce alcohol's interoceptive effects in rats, supporting their potential as treatments for alcohol use disorder.

Increased alcohol self-administration following repeated Toll-like receptor 3 agonist treatment in male and female rats

This study shows that TLR3 agonism increases alcohol consumption in rats, with females being more sensitive to lower doses than males.

The toll-like receptor 7 agonist imiquimod increases ethanol self-administration and induces expression of toll-like receptor related genes

This study shows that TLR7 activation with imiquimod increases ethanol self-administration and induces TLR-related gene expression in rats, with sex-specific effects on drinking behavior and molecular responses.

RTICBM-74 is a Brain-Penetrant CB1 Receptor Allosteric Modulator that Reduces Alcohol Intake in Rats

The paper tests a CB1 receptor NAM, RTICBM-74, showing it reduces alcohol intake in rats without affecting locomotion or sucrose self-administration.

Exposure to the predator odor TMT induces early and late differential gene expression related to stress and excitatory synaptic function throughout the brain in male rats

This study examines gene expression changes in male rats after TMT exposure, showing early and late molecular adaptations related to stress and excitatory synaptic function.