Leon G. Coleman

This study shows that chronic intermittent ethanol exposure in female mice leads to increased ethanol tolerance and persistent memory and anxiety-like behavioral changes during abstinence.

The paper shows that pro-inflammatory microglia increase IRF7 levels and ethanol self-administration in rats during early abstinence, which is reduced by minocycline treatment.

This study shows that chronic intermittent ethanol vapor exposure increases IRF7 levels in brain regions associated with alcohol self-administration and alters excitatory/inhibitory balance, contributing to escalated drinking.

This study shows that proinflammatory microglia contribute to neuronal death and hyperkatifeia during prolonged abstinence from binge alcohol in mice.

This study identifies a distinct reactive microglial phenotype in human AUD that activates astrocytes, contributing to neurodegeneration and heavy drinking.

This study shows alcohol use reduces anti-PD1 immunotherapy efficacy in cancer patients and mouse models by impairing T cell function and anti-tumor immunity.

This study identifies neuronal lysosomal acid lipase (LAL) loss as a driver of amyloid pathology in Alzheimer's disease by linking disrupted lipophagy to Aβ accumulation and cognitive deficits.

This study shows that xylazine and fentanyl co-administration in mice delays wound healing, while neither drug alone does so at tested doses.

This study examines temporal changes in extracellular vesicle (EV) protein cargo in burn-injury patients and mice, showing distinct immune reprogramming effects at early and late post-injury stages.