Oncolytic vaccinia virus expression of a defined peptide-MHCI complex as a precision cancer immunotherapy platform
Shae J Komant, Jun Li Wang, Nicole A. Favis, Cyril Alex, David H. Evans, Ryan S. Noyce, Troy A. Baldwin
This study shows that oncolytic vaccinia virus expressing peptide-MHC-I complexes can effectively stimulate CD8+ T cell responses and enhance tumor clearance in cancer models.
bioRxiv · Aug 16, 2024 · PreprintImmunology