Pluripotency and Transcriptional Pausing Disrupt Circadian Rhythms to Facilitate the Enrichment of Cancer Stem Cells
Edward A. Gonzalez, Dahui Wang, Maciej Jeziorek, Shahd Mohamed, Lauren S. Sherman, Premananda Indic, Patricia Soteropoulos, Mainul Hoque, Seth Raphael Goldman, Karen Adelman, Lanjing Zhang, Pranela Rameshwar, Jean‐Pierre Etchegaray
This study shows that disrupting circadian rhythms through pluripotency factors and transcriptional pausing promotes cancer stem cell enrichment in TNBC, correlating with poor patient outcomes.
bioRxiv · Sep 11, 2026 · PreprintCancer Biology