Karen Adelman

The paper identifies H3K36 methylation as critical for maintaining transcriptome fidelity in metazoans by suppressing aberrant initiation in heterochromatin.

This study shows that disrupting circadian rhythms through pluripotency factors and transcriptional pausing promotes cancer stem cell enrichment in TNBC, correlating with poor patient outcomes.

This study identifies elongin B as a key regulator of Pol2 elongation in H3K27M-mutant diffuse midline glioma, showing its role in maintaining chromatin and transcriptional dysregulation.

This study identifies IWS1 as a modular scaffold that organizes the transcription elongation complex through its disordered region, revealing its role in recruitment and stimulation of elongation.

This study identifies MECOM's role in blocking differentiation via CEBPA repression, showing that targeting this regulatory element can promote differentiation and reduce leukemia burden in AMLs.

This study shows CDK12 inhibition both downregulates and upregulates gene expression, with implications for cancer therapy.

This paper introduces GTACs, bispecific antibodies that selectively downregulate GPCRs via endocytosis and lysosomal degradation, showing high potency and selectivity for therapeutic targets.

The paper reanalyzes data to show H4K20me1 is not a mark of transcriptional silencers in Drosophila and human, and instead is associated with active transcription.

The paper investigates how the Restrictor complex suppresses non-coding RNA transcription by slowing RNA polymerase II elongation, preventing transcriptional interference at divergent promoters.

The paper investigates how AR-bound CREs influence gene expression through epigenetic changes and chromatin looping, finding that contact frequency with promoters drives expression.

This study shows Notch1 activates transcription by releasing paused RNA Pol II without requiring chromatin accessibility changes.

The paper investigates the role of RNA polymerase II pausing in spermatogenesis, showing it is essential for gene expression and meiosis completion.

The paper identifies direct SWI/SNF targets and reveals EP400 as a compensatory remodeler, showing synthetic lethality in cancer and predicting SWI/SNF dependence from chromatin state.

The paper performs genome-scale Perturb-seq to map genotype-phenotype relationships, uncovering new gene functions and stress-specific mitochondrial regulation.

The paper identifies sequence features that influence RNA polymerase II elongation potential by screening thousands of transcribed regions using INSERT-seq.

This study shows that NIPBL and WAPL regulate cohesin activity to control chromatin folding and gene expression, with their relative levels determining transcriptional outcomes.

The paper shows co-transcriptional splicing and 3' end cleavage are functionally linked in mammalian erythropoiesis, with splicing delays and intron retention affecting cleavage efficiency.

The paper investigates the differential requirements for MAML1 in Notch-dependent transcription at HES4 and DTX1, showing distinct functional roles of MAML1 regions and interactions with p300.

The paper shows the Integrator complex destabilizes paused RNA polymerase II at promoters, leading to termination of non-productive transcription.

This study shows NF-Y maintains nucleosome-depleted regions at promoters to ensure accurate transcription initiation, preventing aberrant gene expression.

The paper identifies PCIF1 as the first human m6Am methyltransferase and shows it regulates gene expression by suppressing cap-dependent translation through m6Am methylation.

The paper identifies hundreds of novel recursive splicing sites in Drosophila introns, showing they are more accurately spliced and often located in long introns involved in development.

The paper uses high-depth TSS mapping in D. melanogaster to identify novel initiation events and characterize enhancer-associated RNAs (eRNAs) in a developmental context.

The paper measures splicing rates genome-wide in Drosophila to understand how gene architecture affects splicing efficiency and accuracy.

This study replaces H3K36 with arginine in Drosophila to show H3K36 methylation maintains transcriptome fidelity through post-transcriptional mechanisms involving polyadenylation.