R-Spondin Mimetic, SZN-043, Induced Proliferation and Expression of Wnt Target Genes, Two Impaired Features in Human Alcohol-Associated Liver Disease
Trevor Fisher, Mehaben Patel, Shalaka Deshmukh, Darshini Shah, Chenggang Lu, Maureen R. Newman, Jay Ye, Russell B. Fletcher, Geertrui F. Vanhove, Jay Tibbitts, Yang Li, Nicholas James Skill, Zhihong Yang, Suthat Liangpunsakul, Hélène Baribault
The paper shows that SZN-043, an R-Spondin mimetic, promotes hepatocyte proliferation and Wnt target gene expression in ALD models.
bioRxiv · Nov 19, 2024 · PreprintPathology