Yang Li

A targeted bispecific TGFBR2 antagonist antibody demonstrates cell selectivity and enhanced potency on human fibroblasts

The paper develops a bispecific antibody targeting TGFBR2 on human fibroblasts, showing cell selectivity and enhanced potency while avoiding systemic toxicity.

R-Spondin Mimetic, SZN-043, Induced Proliferation and Expression of Wnt Target Genes, Two Impaired Features in Human Alcohol-Associated Liver Disease

The paper shows that SZN-043, an R-Spondin mimetic, promotes hepatocyte proliferation and Wnt target gene expression in ALD models.

Targeted protein degradation systems to enhance Wnt signaling

The paper describes the development of new antibodies that enhance Wnt signaling through targeted protein degradation by sequestering E3 ligases.

BRAIDing receptors for cell specific targeting

The paper introduces a cell-specific targeting strategy called BRAID, validated using the WNT/{beta}-catenin system, showing it can induce signaling specifically on hepatocytes.