Russell B. Fletcher

A targeted bispecific TGFBR2 antagonist antibody demonstrates cell selectivity and enhanced potency on human fibroblasts

The paper develops a bispecific antibody targeting TGFBR2 on human fibroblasts, showing cell selectivity and enhanced potency while avoiding systemic toxicity.

R-Spondin Mimetic, SZN-043, Induced Proliferation and Expression of Wnt Target Genes, Two Impaired Features in Human Alcohol-Associated Liver Disease

The paper shows that SZN-043, an R-Spondin mimetic, promotes hepatocyte proliferation and Wnt target gene expression in ALD models.

Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia

The paper identifies non-neuronal cell types in the olfactory system expressing SARS-CoV-2 entry genes, suggesting indirect mechanisms for COVID-19-associated anosmia.

clusterExperiment and RSEC: A Bioconductor package and framework for clustering of single-cell and other large gene expression datasets

The paper introduces clusterExperiment, a Bioconductor package for clustering large gene expression datasets using Resampling-based Sequential Ensemble Clustering (RSEC) to identify biologically meaningful subtypes.

Slingshot: Cell lineage and pseudotime inference for single-cell transcriptomics

Slingshot builds a cluster-level minimum spanning tree to find branching lineages without fixing their number, then fits simultaneous principal curves for stable per-lineage pseudotimes.