Evolutionary plasticity of regulatory--catalytic coupling in mono- and poly-ADP-ribosyl transferases
Makwana Milee, Shambhavi Khare, Shanavas P Greeshma, Ghazala Rahman, Anamika Bhargava, Eerappa Rajakumara
The paper investigates how regulatory and catalytic domains of ADP-ribosyltransferases co-evolve, showing functional complementarity across species and enzyme classes.
bioRxiv · Oct 19, 2026 · PreprintBiochemistry