Eerappa Rajakumara

Direct engagement of mycobacterial RadA by c-di-AMP at a non-catalytic site suppresses its DNA-stimulated ATPase activity

This study shows c-di-AMP binds to Mycobacterium smegmatis RadA at a non-catalytic site, reducing its DNA-stimulated ATPase activity.

Evolutionary plasticity of regulatory--catalytic coupling in mono- and poly-ADP-ribosyl transferases

The paper investigates how regulatory and catalytic domains of ADP-ribosyltransferases co-evolve, showing functional complementarity across species and enzyme classes.

Conformational Diversity and Interaction Signatures of NADH across protein families

This study analyzes NADH conformation and interaction patterns across 345 protein structures to uncover general principles of cofactor recognition and interaction.

Allosteric activation of PARP2 self-PARylation by SUMO constrains DNA break-dependent catalytic Function

This study shows SUMO binds to PARP2, enhancing its self-PARylation but reducing DNA-dependent catalytic activity, revealing a new regulatory mechanism in DNA repair.

Computational insights into mechanism of AIM4-mediated inhibition of aggregation of TDP-43 protein implicated in ALS and evidence for in vitro inhibition of liquid-liquid phase separation (LLPS) of TDP-432C-A315T by AIM4.

This study uses computational methods to identify AIM4's binding site on TDP-43 and shows it inhibits LLPS of a TDP-43 mutant in vitro.