Suppressing microtubule detyrosination augments AAV2 endosomal escape and gene delivery.
Shefali Tripathi, Shamshul Huda, Joydipta Kar, Dinesh Chandra, Jayandharan. R. Giridhara, Nitin Mohan
This study shows that inhibiting microtubule detyrosination improves AAV2 endosomal escape and gene delivery in cells and mouse models.
bioRxiv · Aug 12, 2025 · PreprintCell Biology