Recent Bovine HPAI H5N1 Isolate is Highly Virulent for Mice, Rapidly Causing Acute Pulmonary and Neurologic Disease
Thomas Tipih, Vignesh Mariappan, Claude Kwe Yinda, Kimberly D. Meade-White, Matthew C. Lewis, Atsushi Okumura, Natalie McCarthy, Ekaterina S Altynova, Shanna S. Leventhal, Trenton Bushmaker, Chad S. Clancy, Emmie de Wit, Vincent Jacobus Munster, Heinz Feldmann, Kyle Rosenke
This study compares the virulence of recent bovine and non-bovine HPAI H5N1 isolates in mice, finding the bovine isolate causes severe respiratory and neurologic disease.
Nature Communications · Jul 1, 2025Peer-reviewedMicrobiology