Epidermal Resident Memory T Cell Fitness Requires Antigen Encounter in the Skin
E. H. Weiss, Toshiro Hirai, Haiyue Li, Andrew Liu, Shannon Baker, Ian Magill, Jacob E. Gillis, Youran R Zhang, Torben Ramcke, Kazuo Kurihara, David Masopust, Niroshana Anandasabapathy, Harinder Singh, David Zemmour, Laura K. Mackay, Daniel H. Kaplan
This study shows that antigen encounter in the epidermis enhances TRM persistence and proliferation through TGF{beta} signaling and TGF{beta}RIII expression.
eLife · Dec 30, 2025Peer-reviewedImmunology