David Masopust

This study shows that blocking TGFβ signaling in TCR-engineered T cells and enhancing antigen processing in tumor cells improves their therapeutic effectiveness against pancreatic ductal adenocarcinoma.

The paper compares mouse and human tumor microenvironments, identifying conserved and species-specific features in immune composition and gene expression programs.

This study shows that antigen encounter in the epidermis enhances TRM persistence and proliferation through TGF{beta} signaling and TGF{beta}RIII expression.

This study develops an algorithm to analyze T cell migration dynamics using clustering and Hidden Markov Models, finding CD8+ T cells exhibit two distinct migration states in melanoma tumors.

The paper benchmarks somatic mutation detection in noncancerous cells using single-cell and single-molecule whole-genome sequencing to assess platform-specific biases and their impact on mutation detection.

This study shows that IL-7 and IL-15 collaborate to support memory CD8+ T cells, with IL-7R required for self-renewal and IL-15 imposing dependence on IL-7R.

The paper uses a biophysical model of the SARS-CoV-2 viral cycle to identify antiviral targets by analyzing parameter sensitivity and pairwise interactions.