Patient-Derived Inner Ear Organoids as a Disease Modeling and Therapy Validation Platform For Hereditary Inner Ear Disorders
Esther Fousert, Winnie M. C. van den Boogaard, Amy W. A. Lucassen, Shantha D. Udayappan, Jaap Oostrik, Peter Paul G. van Benthem, Hannie Kremer, Erwin van Wijk, Wouter H. van der Valk, Erik de Vrieze, Heiko Locher
This study develops patient-derived inner ear organoids to evaluate antisense oligonucleotide therapies for hereditary hearing loss, showing effective ASO uptake and splice correction in disease models.
bioRxiv · Jul 20, 2026 · PreprintNeuroscience