Author

Peter Paul G. van Benthem

Leiden University Medical CenterORCID 0000-0002-7946-1912Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Heiko LocheriD· 2 shared Wouter H. van der ValkiD· 2 shared Amy W. A. LucasseniD· 1 shared Carl A. Nist-LundiD· 1 shared Daniel OsorioiD· 1 shared Edward S. A. van BeeleniD· 1 shared Erik de VriezeiD· 1 shared Erwin van WijkiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersNeuroscience

Heiko LocherORCID

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Author profile →

2 papers

Recent·Most cited

Patient-Derived Inner Ear Organoids as a Disease Modeling and Therapy Validation Platform For Hereditary Inner Ear Disorders

Esther Fousert, Winnie M. C. van den Boogaard, Amy W. A. Lucassen, Shantha D. Udayappan, Jaap Oostrik, Peter Paul G. van Benthem, Hannie Kremer, Erwin van Wijk, Wouter H. van der Valk, Erik de Vrieze, Heiko Locher

This study develops patient-derived inner ear organoids to evaluate antisense oligonucleotide therapies for hereditary hearing loss, showing effective ASO uptake and splice correction in disease models.

bioRxiv · Jul 20, 2026 · PreprintNeuroscience

A Single-Cell Level Comparison of Human Inner Ear Organoids and the Human Cochlea and Vestibular Organs

Wouter H. van der Valk, Edward S. A. van Beelen, Matthew R. Steinhart, Carl A. Nist-Lund, Daniel Osorio, John C.M.J. de Groot, Liang Sun, Peter Paul G. van Benthem, Karl R. Koehler, Heiko Locher

This study compares single-cell transcriptomic profiles of human inner ear organoids with fetal and adult inner ear tissues to assess their ability to model inner ear disorders.

Cell Reports · Jun 1, 2023Peer-reviewedDevelopmental Biology