Maternal obesity may disrupt offspring metabolism by inducing oocyte genome hyper-methylation via increased DNMTs
Shuo Chao, Jun Lu, Lijun Li, Hongyan Guo, Kuipeng Xu, Ning Wang, Shu‐Xian Zhao, Xiao-Wen Jin, Shao-Ge Wang, Shen Yin, Wei Shen, Minghui Zhao, Gui‐An Huang, Qing‐Yuan Sun, Zhao‐Jia Ge
This study shows maternal obesity causes oocyte genome hyper-methylation via increased DNMTs, which can be partially transmitted to F2 offspring, and melatonin reduces this hyper-methylation through the cAMP/PKA/CREB pathway.
eLife · Dec 6, 2024Peer-reviewedDevelopmental Biology