Ning Wang

This study shows Themis regulates T cell exhaustion by controlling TCR and PD-1 signaling, with loss of Themis causing severe immunopathology in chronic viral infection.

This study shows maternal obesity causes oocyte genome hyper-methylation via increased DNMTs, which can be partially transmitted to F2 offspring, and melatonin reduces this hyper-methylation through the cAMP/PKA/CREB pathway.

The paper investigates how intermittent hypoxia increases H3K27 acetylation through ROS-dependent mechanisms and shows that this is regulated by H3S28 phosphorylation.

The paper examines DNA replication timing in iPSCs, finding that some exhibit delayed replication at heterochromatic regions, which persists through differentiation and may affect their quality.

This study identifies genetic regulators of DNA replication timing in human pluripotent stem cells, revealing a histone code and combinatorial regulatory mechanisms.

The paper introduces SCIRA, a method to detect tumor suppressor events in single-cell RNA-Seq data by inferring regulatory activity of tissue-specific transcription factors, improving sensitivity over differential expression.

This study identifies an upstream open reading frame (uORF) in the 5' UTR of chicken PPARγ1 that represses its translation.