Author

Hongyan Guo

Peking University Third HospitalORCID 0000-0001-6917-5341Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Hongyan Guo2 papers · State Key Laboratory of Seed Innovation, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:metabolomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Alfonso H.W. NganiD· 1 shared Alice S.T. WongiD· 1 shared Carmen Chak‐Lui WongiD· 1 shared Chi Bun ChaniD· 1 shared Gui‐An Huang· 1 shared Jiangwen ZhangiD· 1 shared Jing MaiD· 1 shared Jun LuiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Alfonso H.W. NganORCID

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2 papers

Recent·Most cited

Cancer BiologyCell ReportsPeer-reviewedDec 18, 2024

P-cadherin mechanoactivates tumor- mesothelium metabolic coupling to promote ovarian cancer metastasis

Jing Ma, Sally Kit Yan To, Katie Sze Wai Fung…·Alice S.T. Wong

This study shows that P-cadherin-mediated mechanical forces on mesothelial cells enhance lipid production in ovarian cancer cells, promoting metastasis through lactate-driven lipogenesis.

13 citations

humanbulk RNA-seq

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Developmental BiologyeLifePeer-reviewedDec 6, 2024

Maternal obesity may disrupt offspring metabolism by inducing oocyte genome hyper-methylation via increased DNMTs

Shuo Chao, Jun Lu, Lijun Li…·Zhao‐Jia Ge

This study shows maternal obesity causes oocyte genome hyper-methylation via increased DNMTs, which can be partially transmitted to F2 offspring, and melatonin reduces this hyper-methylation through the cAMP/PKA/CREB pathway.

17 citations

mouseDNA methylation

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