Blocking the ability of huntingtin to bind membranes: a therapeutic strategy for Huntingtons disease
Chathuranga Siriwardhana, Adewale Adegbuyiro, Faezeh Sedighi, Alyssa R. Stonebraker, Sharon Leonard, Maryssa A. Beasley, Adam Skeens, Blake Mertz, Werner J. Geldenhuys, Justin A. Legleiter
This study evaluates blocking huntingtin membrane binding as a therapeutic strategy for HD, identifying two compounds that alleviate HD phenotypes in C. elegans.
bioRxiv · Jul 17, 2024 · PreprintBiophysics