Author

Justin A. Legleiter

University of Nevada, RenoORCID 0000-0002-5262-1867Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Adam Skeens· 1 shared Adewale AdegbuyiroiD· 1 shared Alyssa R. StonebrakeriD· 1 shared Benjamin S. RutledgeiD· 1 shared Blake MertziD· 1 shared Carter J. WilsoniD· 1 shared Chathuranga Siriwardhana· 1 shared Edward A. FoniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

Adam Skeens

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

STIP1/HOP Promotes the Formation of Cytotoxic α-Synuclein Oligomers

Benjamin S. Rutledge, Carter J. Wilson, Rachel M. Lau, Juan Camilo Jurado-Coronel, Esther del Cid‐Pellitero, Mikko Karttunen, Thomas M. Durcan, Edward A. Fon, Marco A. M. Prado, Justin A. Legleiter, Martin L. Duennwald, Wing‐Yiu Choy

This study identifies how STIP1/HOP interacts with a-Syn to promote toxic oligomer formation in synucleinopathies.

Molecular Neurodegeneration Advances · Apr 24, 2026Peer-reviewedBiochemistry

Blocking the ability of huntingtin to bind membranes: a therapeutic strategy for Huntingtons disease

Chathuranga Siriwardhana, Adewale Adegbuyiro, Faezeh Sedighi, Alyssa R. Stonebraker, Sharon Leonard, Maryssa A. Beasley, Adam Skeens, Blake Mertz, Werner J. Geldenhuys, Justin A. Legleiter

This study evaluates blocking huntingtin membrane binding as a therapeutic strategy for HD, identifying two compounds that alleviate HD phenotypes in C. elegans.

bioRxiv · Jul 17, 2024 · PreprintBiophysics