Author

Sharon Tu

University of Southern California

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Jasper Rubin-Sigler· 2 shared Jianyang ZengiD· 2 shared Johnathan Cooper‐KnockiD· 2 shared Justin K. IchidaiD· 2 shared Michael P. SnyderiD· 2 shared Philip S. TsaoiD· 2 shared Sai ZhangiD· 2 shared Akshay BhingeiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetics

Jasper Rubin-Sigler

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2 papers

Recent·Most cited

Deconvolution of polygenic risk score in single cells unravels cellular and molecular heterogeneity of complex human diseases

Sai Zhang, Hantao Shu, Jingtian Zhou, Jasper Rubin-Sigler, Xiaoyu Jenny Yang, Yuxi Liu, Johnathan Cooper‐Knock, Emma Monte, Chenchen Zhu, Sharon Tu, Han Li, Mingming Tong, Joseph R. Ecker, Justin K. Ichida, Yin Shen, , Michael P. Snyder

This paper introduces scPRS, a deep learning model that deconvolves polygenic risk scores at the single-cell level to uncover cellular and molecular disease mechanisms in complex human diseases.

bioRxiv · May 14, 2024 · PreprintGenetics

Antisense oligonucleotide depletion of CCDC146 is a broad-spectrum therapeutic strategy for ALS

Sai Zhang, Tobias Moll, Jasper Rubin-Sigler, Sharon Tu, Shuya Li, Enming Yuan, Menghui Liu, Marriane King, Elham M. Alhathli, Connie Treanor, Alison E. Twelvetrees, Marcel Weinreich, Sam Bonsall, Calum Harvey, Sarah Gornall, , Michael P. Snyder

The paper identifies CCDC146 as a modifier of ALS survival through primary cilia dysfunction and shows ASO targeting of CCDC146 rescues ALS phenotypes in human and mouse models.

medRxiv · Mar 30, 2024 · PreprintGenetic & Genomic Medicine