Alison E. Twelvetrees

This study shows ESR1 fusions form chromatin-anchored condensates that remodel nuclear architecture, supporting endocrine resistance and tumour progression.

The paper introduces a universal protein ladder to standardize FRET assays across different platforms and experimental conditions.

This study shows how different IDRs in CBP regulate its condensate properties, affecting gene expression and histone acetylation.

This study investigates the conformational flexibility of kinesin-1 using biophysical methods, revealing its open structure without cargo and insights into autoinhibition.

The paper identifies CCDC146 as a modifier of ALS survival through primary cilia dysfunction and shows ASO targeting of CCDC146 rescues ALS phenotypes in human and mouse models.