Author

Shuya Li

Johns Hopkins UniversityORCID 0000-0002-7263-0365Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Akshay BhingeiD· 1 shared Alison E. TwelvetreesiD· 1 shared Allan Christian ShawiD· 1 shared Anna Avila· 1 shared Antonello BonciiD· 1 shared Calum HarveyiD· 1 shared Charlotte H. van DijkiD· 1 shared Cleide Dos Santos SouzaiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Akshay BhingeORCID

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2 papers

Recent·Most cited

Neuronal LAG3 facilitates pathogenic α-synuclein neuron-to-neuron propagation

Xiuli Yang, Deok Jeong, Graziella Madeo, Ramhari Kumbhar, Ning Wang, Lili Niu, Junkai Hu, Shuya Li, Kundlik Gadhave, Rong Chen, Fatih Akkentli, Creg J. Workman, Dario A.A. Vignali, Mingyao Ying, Antonello Bonci, , Xiaobo Mao

This study shows neuronal LAG3 is essential for α-synuclein propagation and neurodegeneration in Parkinson's disease, suggesting LAG3 as a therapeutic target.

bioRxiv · Jan 3, 2025 · PreprintNeuroscience

Antisense oligonucleotide depletion of CCDC146 is a broad-spectrum therapeutic strategy for ALS

Sai Zhang, Tobias Moll, Jasper Rubin-Sigler, Sharon Tu, Shuya Li, Enming Yuan, Menghui Liu, Marriane King, Elham M. Alhathli, Connie Treanor, Alison E. Twelvetrees, Marcel Weinreich, Sam Bonsall, Calum Harvey, Sarah Gornall, , Michael P. Snyder

The paper identifies CCDC146 as a modifier of ALS survival through primary cilia dysfunction and shows ASO targeting of CCDC146 rescues ALS phenotypes in human and mouse models.

medRxiv · Mar 30, 2024 · PreprintGenetic & Genomic Medicine